Endocrine Abstracts

Introduction: Brown tumor is a rare benign bone lesion with incidence ranging from 1.5% in primary hyperparathyroidism to 13% in secondary hyperparathyroidism. Common sites of involvement are pelvis, femur and ribs, but may appear in any bone. Since the incidence of thyroid disease is higher among patients with hyperparathyroidism than the general population, these lesions must be distinguished from metastases from thyroid carcinoma.We present a patient ...

Visfatin is a newly discovered adipocyte hormone. Recent studies showed a possible relationship between diabetes mellitus and visfatin level. But the effect of visfatin on the insulin resistance was not well understood. The aim of the present study was to explore the relation of visfatin with insulin resistance in patients with prediabetes and diabetes.We included a total of 128 persons in the study and of these 128 persons, 36 were diabetic, 69 were pre...

The relation between obesity and diabetes mellitus is known for long periods and this relation is based on insulin resistance. Recent studies showed that epicardial adipose tissue thickness measured by echocardiography is the marker of the visceral adipose tissue and cardiovascular risk. Visfatin is a new described adipokine and it has been showed to have mRNA expression in epicardial adipose tissue. There is a conflict about the role of visfatin on obesity, insulin resistance...

Introduction: To date, several mutations have been identified as the underlying cause of hypogonadotropic hypogonadism. However, they account for a small minority of cases, suggesting that other genes play a significant role in the pathogenesis. The aim of the present study was to examine the prevalence of KAL1, GnRH1, GnRHR, PROK2 and PROKR2 mutations. Because it has several advantages over traditional screening methods, multiplex ligation dependent probe amplification (MLPA)...

Introduction: The evidence shows that the prevalence of metabolic syndrome is increased in patients with hypogonadism. However, much of the data regarding this association comes from the elderly patients with obesity, hypertension or type 2 diabetes. The total testosterone levels alter physiologically in these conditions and thus can falsify the association. We aimed to investigate the prevalence of the metabolic syndrome in young adults with hypogonadism who do not have any c...

The high-density lipoprotein (HDL) levels are decreased in paitents with hypogonadotropic hypogonadism (HH). Although testosteron regulates lipoprotein metabolism, the effect of testosterone replacement therapy on HDL metabolism is not clearly shown in HH. The aim of this study is to determine the effects of testesterone replacement on HDL subfractions in young patients with HH. Forty-three cases with HH (mean age 21±2.45 years) were enrolled. Fifty-one healthy volunteer ...

Obesity is a risk factor for calcaneal spur (CS) formation which is supposed to originate from chronic plantar fasciitis. But histological findings support the thesis that ‘plantar fasciitis’ is a degenerative fasciosis without inflammation. Diabetes mellitus may contribute to the risk of CS by decreased ability of tissue repair and increased reactive ossification. Thus, we aimed to determine CS incidence in asymptomatic obese subjects with and without type 2 diabete...

Introduction: Intensive insulin treatment in obese patients with type 2 diabetes (T2DM) is often difficult. Insulin dosages are much higher, which further increase weight gain and the risk of hypoglycemia. Glucagon like peptide 1 receptor agonists (GLP-1RAs) are the promising treatment modalities causing weight loss and reducing the risk of hypoglycemia. There is no published data about the effect of adding on GLP1RAs to obese T2DM patients with un-controlled glucose levels un...

Introduction: Visceral adipose tissue (VAT) is closely related to metabolic derangement, such as dyslipidemia insulin resistance and type 2 diabetes. Also, there is an increase in deposition of visceral adipose tissue in hypogonadal subjects. The visceral adiposity index (VAI) is a sex-specific mathematical index, based on waist circumference (WC), body mass index (BMI), triglycerides (TG) and HDL cholesterol (HDL) levels, indirectly expressing visceral adipose function. We in...

Hypogonadism is associated with increased body fat content and insulin resistance. Many associations including ADA, IDF and EASD declare that waist circumference is a reliable measure of visceral adiposity and may account for insulin resistance. Our observations in young male patients with idiopathic hypogonadotrophic hypogonadism (IHH) are opposite. Thus, we aimed to compare body fat content and anthropometric measurements between patients and age-matched eugonadal healthy co...